Norepinephrine in Septic Shock: A Mixed Blessing
نویسندگان
چکیده
منابع مشابه
Septic shock--vasopressin, norepinephrine, and urgency.
Septic shock is one of the most challenging problems in critical care medicine. Shock due to sepsis accounts for many of the deaths in medical and surgical intensive care units.1-4 It is estimated that septic shock results in approximately 215,000 deaths per year in the United States, a number similar to the number of deaths from acute myocardial infarction. However, the two disorders are not s...
متن کاملManagement of septic shock with a norepinephrine-based haemodynamic algorithm.
UNLABELLED Management of septic shock (SS) with a norepinephrine (noradrenaline)-based haemodynamic algorithm. INTRODUCTION The choice of the best vasopressor for haemodynamic management of septic shock is controversial. Nevertheless, very few studies have been focused on evaluating different management algorithms. The aim of this study was to evaluate the performance of a norepinephrine (NE)...
متن کاملNorepinephrine kinetics and dynamics in septic shock and trauma patients.
BACKGROUND There is considerable variability in the inter-patient response to norepinephrine. Pharmacokinetic studies of dopamine infusion in volunteers and in patients have also shown large variability. The purpose of this study was to define the pharmacokinetics of norepinephrine in septic shock and trauma patients. METHODS After Ethical Committee approval and written informed family consen...
متن کاملArginine vasopressin in septic shock: supplement or substitute for norepinephrine?
In the current issue of Critical Care, Simon and coworkers investigated the effects of first-line arginine vasopressin (AVP) on organ function and systemic metabolism compared with norepinephrine in a pig model of fecal peritonitis. AVP was titrated according to the mean arterial pressure suggesting a vasopressor rather than a hormone replacement therapy. The study provides some evidence for th...
متن کاملVasopressin versus norepinephrine infusion in patients with septic shock.
BACKGROUND Vasopressin is commonly used as an adjunct to catecholamines to support blood pressure in refractory septic shock, but its effect on mortality is unknown. We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors. METHODS In this multicente...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2020
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.202006-2301ed